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Institute of Physiology
University of Freiburg
Hermann-Herder-Str. 7
79104 Freiburg
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Physiology I
Prof. Dr. Marlene Bartos
Tel.: +49 (0)761 203 5194
Fax.: +49 (0)761 203 5204


Physiology II
Prof. Dr. Bernd Fakler
Tel. +49 761 203-5176
Fax +49 761 203-5191
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  • Schwenk J, Fakler BFolding unpredictedScience 366 (6470) : 1194-1194http://doi.org/10.1126/science.aaz8642
  • Müller CS, Bildl W, Klugbauer N, Haupt A, Fakler B, Schulte UHigh-Resolution Complexome Profiling by Cryoslicing BN-MS AnalysisJove-j Vis Exp 152: 1-10
  • Schwenk J, Boudkkazi S, Kocylowski M, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, SprengelR, Kulik A, Roeper J, Schulte U, Fakler BAn ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its PlasticityNeuron 104: 680-692
  • Tsika AC, Melekis E, Tsatsouli SA, Papageorgiou N, Maté MJ, Canard B, Coutard B, Bentrop D, Spyroulias GADeciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro DomainJ Mol Biol 431 (12) : 2283-2297http://dx.doi.org/10.1016/j.jmb.2019.04.013
  • Makrynitsa G, Ntonti D, Marousis KD, Birkou M, Matsoukas MT, Asami S, Bentrop D, Papageorgiou N, Canard B, Coutard B, Spyroulias GAConformational plasticity of the VEEV macro domain is important for binding of ADP-riboseJ Struct Biol 206 (1) : 119-127http://dx.doi.org/10.1016/j.jsb.2019.02.008
  • Dinamarca MC, Raveh A, Schneider A, Fritzius T, Früh S, Rem PD, Stawarski M, Lalanne T, Turecek R, Choo M, Besseyrias V, Bildl W, Bentrop D, Staufenbiel M, Gassmann M, Fakler B, Schwenk J, Bettler BComplex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processingNat Commun 10 (1) : 1331http://dx.doi.org/10.1038/s41467-019-09164-3
  • Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde1 DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter DP, Tucker ST, Baukrowitz TA pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channelsScience 363: 875-880
  • 2018

  • Lykouras MV, Tsika AC, Lichière J, Papageorgiou N, Coutard B, Bentrop D, Spyroulias GANMR study of non-structural proteins-part III: 1H, 13C, 15N backbone and side-chain resonance assignment of macro domain from Chikungunya virus (CHIKV)Biomol Nmr Assign 12 (1) : 31-35http://doi.org/10.1007/s12104-017-9775-2
  • 2017

  • Schmidt N, Kollewe A, Constantin C, Henrich S, Ritzau-Jost A, Bildl W, Saalbach A, Hallermann S, Kulik A, Fakler B, Schulte UNeuroplastin and Basigin are essential auxiliary subunits of plasma membrane Ca2+-ATPases and key regulators of Ca2+ clearance Neuron 96: 827-838http://doi.org/10.016/j.neuron.2017.09.038
  • Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle1 J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel MHeteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memoryEmbo J 36 (18) : 2770-2789
  • Birkou M, Chasapis CT, Marousis KD, Loutsidou AK, Bentrop D, Lelli M, Herrmann T, Carthy JM, Episkopou V, Spyroulias GAA Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational PlasticityJ Mol Biol 429 (15) : 2373-2386http://dx.doi.org/10.1016/j.jmb.2017.06.012
  • Brechet A, Buchert R, Schwenk J, Boudkkazi S, Zolles G, Siquier-Pernet K, Schaber I, Bildl W, Saadi A, Bole-Feysot C, Nitschke P, Reis A, Sticht H, Al-Sanna’a N, Rolfs A, Kulik A, Schulte U, Colleaux L, Abou Jamra R, Fakler BAMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual abilityNat Commun 8: 15910http://dx.doi.org/10.1038/ncomms15910
  • Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler BIdentification of Cav2-PKCβ and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling.P Natl Acad Sci Usa 114 (22) : 5707-5712http://dx.doi.org/10.1073/pnas.1616394114
  • Bettler B, Fakler BIonotropic AMPA-type glutamate and metabotropic GABAB receptors: determining cellular physiology by proteomesCurr Opin Neurobiol 45: 16-23http://dx.doi.org/10.1016/j.conb.2017.02.011
  • Sterky FH, Trotter JH, Lee SJ, Recktenwald CV, Du X, Zhou B, Zhou P, Schwenk J, Fakler B, Südhof TCCarbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligandP Natl Acad Sci Usa 114 (7) : E1253-E1262http://doi.org/10.1073/pnas.1621321114
  • Booker SA, Althof D, Gross A, Loreth D, Müller J, Unger A, Fakler B, Varro A, Watanabe M, Gassmann M, Bettler B, Shigemoto R, Vida I, Kulik AKCTD12 auxiliary proteins modulate kinetics of GABA(B) receptor-mediated inhibition in cholecystokinin-containing interneurons.Cereb Cortex 27 (3) : 2318-2334
  • 2016

  • Kim G, Luján, R, Schwenk J, Kelly MH, Aguado C, Watanabe M, Fakler B, Maylie J, Adelman JPMembrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel functionElife 5:e12637: 1-18http://dx.doi.org/10.7554/eLife.12637
  • Schwenk J, Pérez-Garci E, Schneider A, Kollewe A, Gauthier-Kemper A, Fritzius T, Raveh A, Dinamarca MC, Hanuschkin A, Bildl W, Klingauf J, Gassmann M, Schulte U, Bettler B, Fakler BModular composition and dynamics of native GABAB receptors identified by high-resolution proteomicsNat Neurosci 19 (2) : 233-242http://dx.doi.org/10.1038/nn.4198
  • Müller CS, Bildl W, Haupt A, Ellenrieder L, Becker T, Hunte C, Fakler B, Schulte UCryo-slicing Blue Native-Mass Spectrometry (csBN-MS), a Novel Technology for High Resolution Complexome ProfilingMol Cell Proteomics 15 (2) : 669-681http://dx.doi.org/10.1074/mcp.M115.054080
  • 2015

  • Makrynitsa GI, Ntonti D, Marousis KD, Tsika AC, Lichière J, Papageorgiou N, Coutard B, Bentrop D, Spyroulias GANMR study of non-structural proteins--part II: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV)Biomol Nmr Assign 9 (2) : 247-251
  • Althof D, Baehrens D, Watanabe M, Suzuki N, Fakler B, Kulik AInhibitory and excitatory axon terminals share a common nano-architecture of their Cav2.1 (P/Q-type) Ca2+ channelsFront Cell Neurosci 9 (315) : 1-11
  • Melekis E, Tsika AC, Lichière J, Chasapis CT, Margiolaki I, Papageorgiou N, Coutard B, Bentrop D, Spyroulias GANMR study of non-structural proteins-part I: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Mayaro virus (MAYV)Biomol Nmr Assign 9 (1) : 191-195http://dx.doi.org/10.1007/s12104-014-9572-0
  • Argyriou AI, Chasapis CT, Apostolidi M, Konstantinidou P, Stathopoulos C, Bentrop D, Spyroulias GABackbone and side chain NMR assignment, along with the secondary structure prediction of RRM2 domain of La protein from a lower eukaryote exhibiting identical structural organization with its human homologBiomol Nmr Assign 9 (1) : 219-222http://dx.doi.org/10.1007/s12104-014-9578-7
  • 2014

  • Kob P, Vorreiter J, Habicht J, Bentrop D, Wallich R, Nassal MSoluble cysteine-rich tick salvia proteins Salp15 and Irid-1 from E. coli.FEBS Open Bio 5: 42-55http://doi.org/10.1016/j.fob.2014.12.002
  • Lee A, Fakler B, Kaczmarek LK, Isom LLMore Than a Pore: Ion Channel Signaling ComplexesJ Neurosci 46 (34) : 15159-15169
  • Subramaniam M, Althof D, Gispert S, Schwenk J, Auburger G, Kulik A, Fakler B, Roeper JMutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channelsJ Neurosci 34 (41) : 13586-13599http://dx.doi.org/10.1523/JNEUROSCI.5069-13.2014
  • Schwenk J, Baehrens D, Haupt A, Bildl W, Boudkkazi S, Röper J, Fakler B, Schulte URegional Diversity and Developmental Dynamics of the AMPA-Receptor Proteome in the Mammalian BrainNeuron 84 (1) : 41-54http://dx.doi.org/10.1016/j.neuron.2014.08.044
  • Vourtsis DJ, Chasapis CT, Pairas G, Bentrop D, Spyroulias GANMR conformational properties of an Anthrax Lethal Factor domain studied by multiple amino acid-selective labelingBiochem Bioph Res Co 450 (1) : 335-340http://doi.org/10.1016/j.bbrc.2014.05.123
  • Turecek R, Schwenk J, Fritzius T, Ivan kova K, Zolles G, Adelfinger L, Jacquier V, Besseryrias V, Gassmann M, Schulte U, Fakler B, Bettler BAuxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce DesensitizationNeuron 82 (5) : 1032-1044http://dx.doi.org/10.1016/j.neuron.2014.04.015
  • Boudkkazi S, Brechet A, Schwenk J, Fakler BCornichon2 Dictates the Time Course of Excitatory Transmission at Individual Hippocampal SynapsesNeuron 82 (4) : 848-858http://dx.doi.org/10.1016/j.neuron.2014.03.031
  • Apostolidi M, Vourtsis DJ, Chasapis CT, Stathopoulos C, Bentrop D, Spyroulias GA(1)H, (15)N, (13)C assignment and secondary structure determination of two domains of La protein from D. discoideum.Biomol Nmr Assign 8 (1) : 47-51http://dx.doi.org/10.1007/s12104-012-9450-6
  • 2013

  • Ivanovka K, Tureccek R, Fritzius T, Seddik R, Prezeau L, Comps-Agrara L, Pin JP, Fakler B, Besseyrias V, Gassmann M, Bettler BUp-regulation of GABA(B) Receptor Signaling by Constitutive Assembly with the K+ Channel Tetramerization Domain-containing Protein 12 (KCTD12).J Biol Chem 288 (34) : 24848-24856http://dx.doi.org/10.1074/jbc.M113.476770
  • Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimemrmann U, Knipper MOtoferlin Couples to Clathrin-Mediated Endocytosis in Mature Cochlear Inner Hair CellsJ Neurosci 33 (22) : 9508-9519
  • Berkefeld H, Fakler BLigand-Gating by Ca2+ Is Rate Limiting for Physiological Operation of BKca ChannelsJournal of Neuroscience 33 (17) : 7358-7367http://dx.doi.org/10.1523/JNEUROSCI.5443-12.2013
  • 2012

  • Riad Seddik, Jungblut Stefan P, Silander OK, Rajalu M, Fritzius t, Besseyrias V, Jacquier, Fakler B, Gassmann M, Bettler BOpposite Effects of KCTD Subunit Domains on GABAB Receptor-mediated DesensitizationJOURNAL OF BIOLOGICAL CHEMISTRY 287 (4) : 39869-39877http://dx.doi.org/10.1074/jbc.M112.412767
  • Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller C, Bildl W, Baehrens D, Hüber B, Kulik A, Klöcker N, Schulte U, Fakler BHigh-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor ComplexesNeuron 74 (4) : 621-633http://dx.doi.org/10.1016/j.neuron.2012.03.034
  • Harmel N, Cokic B, Zolles G, Berkefeld H, Maruic V, Fakler B, Stein V, Klöcker NAMPA receptors commandeer an ancient cargo exporter for use as an auxiliary subunit for signalingPlos One 7 (1) : e30681http://dx.doi.org/10.1371/journal.pone.0030681
  • Chasapis CT, Kandias NG, Episkopou V, Bentrop D, Spyroulias GANMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligaseProteins 80 (5) : 1484-1489http://dx.doi.org/10.1002/prot.24048
  • Bildl W *, Haupt A *, Müller CS *, Biniossek M, Thumfart JO, Hüber B, Fakler B, Schulte UExtending The Dynamic Range Of Label-Free Mass Spectrometric Quantification Of Affinity PurificationsMol Cell Proteomics 11 (2) : 007955-1-007955-12http://dx.doi.org/10.1074/mcp.M111.007955
  • 2011

  • Lòpez-Hernández T, Ridder MC, Montolio M, Capdevila-Nortes X, Polder E, Sirisi S, Duarri A, Schulte U, Fakler B, Nunes V, Scheper GC, Martinez A, Estévez R, van der Knaap MSMutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autismAm J Hum Genet 88 (4) : 422-432http://dx.doi.org/10.1016/j.ajhg.2011.02.009
  • Chasapis CT, Argyriou AL, Corringer PJ, Bentrop D, Spyroulias GAUnravelling the Conformational Plasticity of the Extracellular Domain of a Prokaryotic nAChR Homologue in Solution by NMRBiochemistry-us 50 (45) : 9681-9683
  • Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kügler S, Fakler B, Oliver DA Synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricityEmbo J 30: 2793-3804
  • Metz M, Gassmann M, Fakler B, Schaeren-Wiemers N, Bettler BDistribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b and 16 in the mouse brainJ Comp Neurol 519 (8) : 1435-1454
  • Schulte U, Müller C, Fakler BIon channels and their molecular environments glimpses and insights from functional proteonmicsSemin Cell Dev Biol 22 (2) : 132-144http://dx.doi.org/10.1016/j.semcdb.2010.09.015
  • 2010

  • Dalkas GA, Chasapis CT, Gkazonis PV, Bentrop D, Spyroulias GAConformational Dynamics of the Anthrax Lethal Factor Catalytic Center.Biochemistry-us 49 (51) : 10767-10769
  • Reisinger E, Meintrup D, Oliver D, Fakler BGene expression associated with the onset of hearing detected by differential display in ratorgan of cortEur J Hum Genet 18 (12) : 1327-1332
  • Berkefeld H, Fakler B, Schulte UCa2+-activated k+ channels: from protein complexes to functionPhysiol Rev 90 (4) : 1437-1459
  • Müller C, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte UQuantitative proteomics of the Cav2 channel nano-environments in the mammalian brainP Natl Acad Sci Usa 107 (34) : 14950-14957
  • Gzonis PV, Dalkas GA, Chasapis CT, Vlamis-Gardikas A, Bentrop D, Spyroulias GAPurification and biophysical characterization of the core protease domain of anthrax lethal factor.Biochem Bioph Res Co 396 (3) : 643-647
  • Schwenk J, Metz M, Zolles G, turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K, Seddik R, Tiao JY, Rajalu M, Trojanova J, Rohde V, Gassmann M, Schuklte U, Fakler B, Bettler BNative GAB(B) receptors are heteromultimers with a family of auxiliary subunitsNature 465: 231-235
  • 2009

  • Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller CS, Thumfart J, Vlachos a, Deller T, Pfeifer A, Fleischmann BK, Roeper J, Fakler B, Klöcker NAssociation with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulationNeuron 62 (6) : 814-825
  • Kandias NG, Chasapis CT, Bentrop D, Episkopou V, Spyroulias GAHigh yield expression and NMR characterization of Arkadia E3 ubiquitin ligase RiNG-H2 finger domainBiochemical and Biophysical Research Communications 378 (3) : 498-502
  • Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klöcker NFunctional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptorsScience 323: 1313-1319
  • 2008

  • Fakler B, Adelman JPControl of K(Ca) channels by calcium nano/microdomainsNeuron 59 (6) : 873-881
  • Berkefeld H, Fakler BRepolarizing responses of BKca-Cav complexes are distinctly shaped by their cav subunitsJ Neurosci 28 (33) : 8238-8245
  • Hardel N, Harmel N, Zolles G, Fakler B, Klöcker NRecycling endosomes supply cardiac pacemaker channels for regulated surface expressionCardiovasc Res 79 (1) : 52-60
  • Schwenk J, Zolles G, Kandias NG, Neubauer I, Kalbacher H, Covarrubias M, Fakler B, Bentrop DNMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexesJ Biol Chem 283 (27) : 18937-18946
  • 2007

  • Allen D, Fakler B, Maylie J, Adelman JPOrganization and regulation of small conductance Ca2+-activated K+ channel multiprotein.J Neurosci 27 (9) : 2369-2376
  • 2006

  • Zolles G, Klöcker N, Wenzel D, Weisser-Thomas J, Fleischmann BK, Roeper J, Fakler BPacemaking by HCN chnallens requires interaction with phosphoinositidesNeuron 52: 1027-1036
  • Oliver D, Schächinger T, Fakler BInteraction of Prestin (SLC26A5) with monovalent intracellular anionsNovartis Found Symp. 273: 244-253
  • Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler BBKca-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signalingScience 314 (5799) : 615-620
  • Oliver D, Taberner AM, Thurm H, Sausbier M, Arntz C, Ruth P, Fakler B, Liberman MCThe role of BKca channels in electrical signal encoding in the mammalian auditory peripheryJournal of Neuroscience 26 (23) : 6181-6189
  • Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler BThe epilepsy linked lgi1 protein assembles into presynaptic kv1 Channels and inhibits inactivation by kvbeta1 Neuron 49Neuron 49 (5) : 697-706

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