Research Group - Claudio Elgueta

Research:

Dendritic processes of cortical neurons do not passively integrate signals but can actively process pre- and post-synaptic information. Glutamatergic principal cells and the diverse classes of GABAergic inhibitory interneurons express different sets of ionic conductances across their dendritic trees enabling them to perform distinct computational operations which greatly enrich the information processing power of cortical circuits. Using a broad array of experimental techniques such as patch clamp, 2-photon uncaging and optogenetics, voltage and Ca²⁺-imaging both in vivo and in vitro combined with neuronal modelling, we aim to understand how the different modes of dendritic integration influence neural network dynamics and animal behavior.

Using 2-Photon in vivo recordings of Ca²⁺ activity in single cells, we investigate how non-linear dendritic events contribute to the hippocampal coding of space in virtual environments.

Using recordings of Ca²⁺ activity in freely-moving mice, we investigate neuronal dynamics during complex behaviors as spatial exploration or social interaction across subsequent days, and simultaneously control neuronal activity using optogenetics.

 claudio.elgueta@physiologie.uni-freiburg.de

Funding:

Publications:

Original papers

• Paschen E, Elgueta C, Heining K, Vieira DM, Kleis P, Orcinha C, Häussler U, Bartos M, Egert U, Janz P, Haas CA (2020) Hippocampal low-frequency stimulation prevents seizure generation in a mouse model of mesial temporal lobe epilepsy. eLife doi: 10.7554/eLife.
  

• Booker SA, Harada H, Elgueta C, Bank J, Bartos M, Kulik A, Vida I (2020) Presynaptic GABA(B) receptors functionally uncouple somatostatin interneurons from the active hippocampal network. eLife, doi: 10.7554/eLife.51156. 
• Elgueta C, Bartos M (2019) Dendritic inhibition differentially regulates excitability of dentate gyrus parvalbumin-expressing interneurons and granule cells. Nat Commun, doi: 10.1038/s41467-019-13533-3.
• Menon V, Thomas R, Elgueta C, Horl M, Osborn T, Hallett PJ, Bartos M, Isacson O, Pruszak J (2019)  Comprehensive cell surface antigen analysis identifies transferrin receptor protein-1 (CD71) as a negative selection marker for human neuronal cells. Stem Cells, doi: 10.1002/stem.3057.
• Arias-Cavieres A, Barrientos GC, Sanchez G, Elgueta C, Munoz P and Hidalgo C (2018) Ryanodine receptor-mediated calcium release has a key role in hippocampal LTD induction. Front Cell Neurosci, doi: 10.3389/fncel.2018.00403. 
• Elgueta C, Schmachtenberg O, Leroy F, Vielma AH, Palacios A (2018) Electrical coupling in A17 cells modulates calcium signaling and GABAergic inhibition in the rod circuitry. Sci Rep, doi: 10.1038/s41598-018-21119-0.
• Gajardo I, Salazar CS, Lopez-Espíndola D, Estay C, Flores-Muñoz C, Elgueta C, Gonzalez-Jamett AM, Martínez AD, Muñoz P, Ardiles AO (2018) Lack of Pannexin 1 alters synaptic GluN2 subunit composition and spatial reversal learning in mice: Front Mol Neurosci, doi: 10.3389/fnmol.2018.00114.
• Yuan M,  Meyer T, Benkowitz C, Savanthrapadian S, Ansel-Bollepalli L,  Foggetti A, Wulff P, Alcami, Elgueta C, Bartos M  (2017) Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition. eLife, doi: 10.7554/eLife.21105.
• Muñoz P, Estay C, Díaz P, Elgueta C, Ardiles A and Lizana P (2016) Inhibition of DNA Methylation Impairs Synaptic Plasticity during an Early Time Window in Rats, Neural Plast,  doi: 10.1155/2016/4783836. 
• Elgueta C, Köhler J, Bartos M (2015) Persistent discharges in dentate gyrus perisoma-inhibiting interneurons require hyperpolarization-activated cyclic nucleotide-gated channel activation J Neurosci, doi: 10.1523/JNEUROSCI.3671-14.2015
• Elgueta C, Vielma AH, Palacios AG, Schmachtenberg O (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Front Cell Neurosci, ; doi: 10.3389/fncel.2015.00006
• Savanthrapadian S., Meyer T, Elgueta C, Booker SA, Vida I, Bartos M (2014) Synaptic properties of SOM- and CCK-expressing cells in dentate gyrus interneuron networks. J Neurosci, doi: 10.1523/JNEUROSCI.5433-13.2014.
• Mallmann RT, Elgueta C, Sleman F, Castonguay J, Wilmes T, van den Maagdenberg A, Klugbauer N (2013) Ablation of Ca(V)2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments. PLoS One, doi: 10.1371/journal.pone.0078598.
• Muñoz P, Humeres A, Elgueta C, Kirkwood A, Hidalgo C, Núñez MT (2011) Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity. J Biol Chem, doi: 10.1074/jbc.M110.213785.
• Vielma A, Delgado L, Elgueta C, Osorio R, Palacios AG, Schmachtenberg O (2010) Nitric oxide amplifies the rat electroretinogram. Exp Eye Res, doi: 10.1016/j.exer.

Review articles

• Bartos M, Elgueta C (2012) Functional characteristics of parvalbumin- and cholecystokinin-expressing basket cells. J Physiol, doi: 10.1113/jphysiol.2011.226175.