Systemic and Cellular Neurophysiology
Temp. Chair of the Institute for Physiology I
How is information processed and encoded in neuronal networks to realize learning, memory and behaviour?
This is one of the most fundamental questions in modern life sciences. We aim to uncover the mechanisms underlying information processing by applying electrophysiological, imaging, molecular and computational approaches.
Synaptically connected pair of a granule cell and a basket cell in the detate gyrus.
Our main objectives are:
- To determine cellular and molecular mechanisms underlying synaptic communication among cortical neurons.
- To examine the cellular basis of network synchronization in the health and diseased brain.
- To identify the rules for induction of synaptic plasticity.
- To elucidate the role of neuron types in cognition and behaviour.
- To examine the mechanisms underlying the emergence of network oscillations during development of neuronal network.
A fundamental and fascinating feature of the mammalian brain is its capacity to acquire and store novel information. However, little progress has been made on how memory is represented in neuronal networks. Our research is focused on understanding the mechanisms underlying the emergence of learning-associated active cell populations, so called cell assemblies, representing new memories. We aim to focus this question on the rodent dentate gyrus (DG), the input region of the hippocampus, known to be functionally vital for acquiring new memories in humans, nonhuman primates and rodents. So far our group efforts have been clarifying the cellular and synaptic properties of neurons and synapses in the DG circuitry and the mechanisms underlying the synchronization of neuronal networks for the encoding of information. Moreover, we have investigated the cellular, synaptic and network mechanisms important for the development of neuronal networks, specifically of GABAergic inhibitory cells. Our major questions which have been brought into sharp focus based on recent scientific observations are as follows:
1. understand the spatial and temporal emergence of learning-associated
cell assemblies representing new
2. delineate the nature and relevance of the major functional
(cellular, synaptic, plasticity) and structural changes
underlying cell assembly formation
3. understand the functional and dynamic characteristics of
synaptic communication among cells and their role in
information processing in cortical microcircuits
4. identify the role of the high variety of GABAergic cells in neuronal network function and cell assembly formation
5. examine dysfunction of cellular components in specific mouse models underlying neuronal diseases
To address these questions we use state-of-the-art techniques which include:
1. imaging and manipulating activity of neuron populations during behaviour at high spatial and temporal resolution
2. dissect and manipulate the
mechanisms underlying synaptic transmission and plasticity on a cell-type and
synapse-specific manner in the living animal
3. record from pairs of neurons in acute slice preparations
4. perform behavioural analysis during in vivo single unit and local field potential recordings
5. apply optophysiological techniques to recruit or silence defined neuron types in specific brain areas
6. combine electrophysiological with computational approaches
- Janz P, Savathrapadian S, Häussler U, Kilias A, Nestel A, Kretz O, Kirsch M, Bartos M, Egert U, Haas C (2016) Synaptic remodeling of entorhinal input contributes to an aberrant hippocampal network in temporal lobe epilepsy. Cereb Cortex doi: 10.1093/cercor/bhw093
- Elgueta C, Köhler J, Bartos M (2015) Persistent discharges in dentate gyrus perisoma-inhibiting interneurons require hyperpolarization-activated cyclic nucleotide-gated channel activation. J Neurosci 35:4131-4139
- Sauer JF, Strüber M, Bartos M (2015) Impaired fast-spiking interneuron function in a genetic mouse model of depression. eLife 2015;10.7554/eLife.04979
- Strüber M, Jonas P, Bartos M (2015) Strength and duration of perisomatic GABAergic inhibition depend on distance between synaptically connected cells. PNAS USA ePub ahead of print; doi:10.1073/pnas.1423628112
- Hainmüller T, Krieglstein K, Kulik A, Bartos M (2014) Joint CP-AMPA and group I mGlu receptor activation is required for synaptic plasticity in dentate gyrus fast-spiking interneurons. PNAS USA 111:13211-13216.
- Savanthrapadian S, Meyer T, Elgueta C, Booker S, Vida I, Bartos M (2014) Synaptic properties of SOM- and CCK-expressing cells in dentate gyrus interneuron networks. J Neurosci 34:8197-8209.
- Mallmann RT, Elgueta C, Sleman F, Castonguay J, Wilmes T, van den Maagdenberg A, Klugbauer N (2013) Ablation of CaV2.1 voltage-gated Ca2+ channels in mouse forebrain generates multiple cognitive impairments. PLoS One 8:e78598. doi: 10.1371/journal.pone.0078598.
- Hosp JA, Strüber M, Yanagawa Y, Obata K, Vida I, Jonas P, Bartos M (2013) Morpho-physiological criteria divide dentate gyrus interneurons into classes. Hippocampus 24:189-203.
- Bartos M, Elgueta C. (2012) Functional characteristics of parvalbumin- and cholecystokinin-expressing basket cells. J Physiol (Lond) 590:669-681.
- Ho EC, Strüber M, Bartos M, Zhang L, Skinner FK (2012) Inhibitory networks of fast-spiking interneurons generate slow population activities due to fluctuations and network multistability. J Neurosci 32:9931-9946.
- Sauer J-F, Strüber M, Bartos M (2012) Interneurons provide circuit-specific depolarization and hyperpolarization. J Neurosci 32:4224-4229.
- Murray AJ, Sauer J, Mcclure CJ, Cheyne LA, Riedel G, Bartos M, Wisden W, Wulff P (2011) Parvalbumin-positive hippocamapl interneurons are required for spatial working but not reference memory. Nat Neurosci 14:297-299.
- Bartos M, Alle H, Vida I (2011) Role of microcircuit structure and input integration in hippocampal interneuron recruitment and plasticity. Neuropharmacol 60:730-739.
- Sauer J-F, Bartos M (2011) Postnatal differentiation of cortical interneuron signalling. Eur J Neurosci 34:1687-1696.
- Sambandan S, Sauer JF, Vida I, Bartos M (2010) Associative plasticity at excitatory synapses facilitates recruitment of fast-spiking interneurons in the dentate gyrus. J Neurosci 30:11826-11837.
- Nörenberg A, Hu H, Vida I, Bartos M, Jonas P (2010) Non-uniform cable properties optimize rapid signaling in fast-spiking GABAergic interneurons. PNAS USA 107:894-899.
- Sauer J, Bartos M (2010) Efficient recruitment of young hippocampal interneurons by early excitatory GABAergic synapses. J Neurosci 30:110-115.
- Wulff P, Ponomarenko AA, Bartos M, Krotkova TM, Fuchs EC, Tort MA, Kopell N, Wisden W, Monyer H (2009) Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin positive interneurons. PNAS USA 106:3561-3566.
- Doischer, D, Hosp, P, Yanagawa, Y, Obata, K, Jonas, P, Vida, I, Bartos, M (2008) Postnatal development of hippocampal basket cells from slow to fast signaling devices. J Neurosci 26:12956-12968.
- Bartos M, Vida I, Jonas P (2007) Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks. Nat Rev Neurosci 8:45-56.
- Vida I, Bartos M, Jonas P (2006) Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates. Neuron 49:107-117 (equal contribution of the authors).
- Bartos M, Vida I, Frotscher M, Meyer A, Monyer H, Geiger JRP, Jonas P (2002) Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks. PNAS USA 99:13222-13227.
- Bartos M, Vida I, Frotscher M, Geiger JRP, Jonas P (2001) Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. J Neurosci 21:2687-2698.
- Bartos M, Sauer J, Kulik A, Vida I (2010) Fast and strong inhibition in the hippocampal circuitry. "Hippocampal Microcircuits: A Computational Modeller's Resource Book", Springer (USA). 1st Edition January 2010.
- Vida I, Bartos M (2006) Gamma oscillations in interneuron networks: a combined experimental-computational approach, in 2nd UniNet workshop: Data, Networks and Dynamics, eds. M Kirkilionis, U Kummer, I Stoleriu, Logos Verlag, Berlin.
- Förster E, Bartos M, Zhao S (2005) Hippocampal slice cultures. In: New Methods for Culturing Cells from Nervous Tissues. BioValley Monographs Vol 1. Karger AG, Basel:1-11.
- Marder E, Manor Y, Nadim F, Bartos M, Nusbaum MP (1998) Frequency control of a slow oscillatory network by a fast rhythmic input: Pyloric to gastric mill interactions in the crab stomatogastric nervous system. Annals of the New York Academy of Sciences, Vol. 860:226-238.